One noted FMS doctor and researcher has theorized that people with fibromyalgia have a high concentration of inorganic phosphates (Pi) in the cell. As the following text taken from a cell physiology reference book points out:
In a reduced pH environment, made more acid by an increase in pyruvate, the cell will naturally develop a greater concentration of Pi, inorganic phosphates. This is likely the result of the last Pi dissociating from the ATP molecule as energy is released. The Pi under normal circumstances would then be recycled and bound to another ADP molecule to form more ATP. But this is not what is happening due to the breakdown in aerobic cellular respiration. Hence, the increase in inorganic phosphates inside the cell.
This increased concentration of Pi then causes the muscle to become fatigued. This is possibly a control mechanism in the cell to prevent the body from using more ATP than is able to be produced. An Increase in inorganic phosphates would also contribute to making the cell environment even more acidic.
The approach taken by this doctor, has been to try to expel inorganic phosphates from the cell using a medication called guaifenesin. I believe that this approach is addressing a symptom of the condition and not the root cause. My thinking is that if the cell is brought back into the correct pH range it is probable that the concentration of Pi would return to normal levels; As the free Pi in the cell is again bound to ADP to become ATP once more.
Related Links |
| The Role of Guaifenesin in Fibromyalgia |