The tyranist's thoughts
I like the zombie movies, especially when they are sci-fi zombie movies. This one is based on a video game that I never played, but all the same, I'll see anything that promises zombies.
So the future is ruled by a mega-corporation, auspiciously named "Umbrella," and they have been mucking about with things that they shouldn't have. The whole system shuts down and a group of operatives are sent into the underground facility to figure out what happened.
As much as I enjoyed the action and the story, there were times that it did feel like I was playing a game and that the plot was being dictated to me. There were quite a few instances of "now go here and do this and then go there and do that." Still, Milla Jovovich is fun to watch and the slick production had enough in common with the "Alien" franchise that I really didn't mind. It isn't the most intelligent horror flick you'll see (but then they rarely are intelligent).
The movie was a little shorter than I expected coming in under two hours, and perhaps that explains a few of the dropped sub-plots. Most of the time they work really hard to distract the audience from the plot though. While it isn't as gory as most zombie flicks and in fact a lot of the gore is of the off-screen variety, there is a ton of violence. Interesting that we are so much more tolerant of the violent than the aftermath thereof. Anyway, as far as zombie movies go, this one was pretty good. It did bear a striking resemblance to Aliens if that movie had been filled with zombies. Since a lot of people liked Aliens perhaps they'll like this. Just don't go in expecting a strong plot and you'll be okay.
Note: The theatre that I saw this in had a messed up projector and about the last 20 minutes of the flick jumped a lot. It was pretty distracting so I hope I didn't miss anything important. Not that they resolved any of the plot holes. I'm just worried about any Skulls I may have missed.

Rish's Reviews
I gotta admit, when I first saw the trailer and TV spots, I thought this movie looked like hot, steaming crap. I didn't go to it, had no intention of doing so, and it wasn't until I read tyranist's positive review that I gave it a chance. And it wasn't half bad.
This was not a great movie, by any stretch. But hey, it was a pretty good movie. It may be that I've just been starved for a zombie flick (wow, how long has it been since you saw zombies on the big screen?), but as derivative as the walking dead sequences were, I got a big thrill out of seeing them again. And remember when George Romero was going to direct this?
I've never been a big Milla Jovavich fan, and I absolutely detest Michelle Rodriguez (is it just me, or is she the spitting image of a bulldog?), but I managed to enjoy the film anyway. Director Anderson's track record is a little shaky: if I hadn't been driven to kill my foster parents by the music of Mortal Kombat, I might have a positive opinion about it; I didn't despise Event Horizon like tyranist did (in fact, I oughtta check it out again for the site), and I felt Soldier was only mediocre, but this film had something over on both of those . . . it was fun.
The final shot of the film was pretty astounding, even if the last ten minutes made no sense at all. But hey, it was all based on a video game, and that medium's exactly not known for its stories.